Pancreatic neuroendocrine tumors: biology, diagnosis,and treatment
نویسندگان
چکیده
منابع مشابه
Pancreatic neuroendocrine tumors: biology, diagnosis, and treatment
Pancreatic neuroendocrine tumors (PNETs), a group of endocrine tumors arising in the pancreas, are among the most common neuroendocrine tumors. The genetic causes of familial and sporadic PNETs are somewhat understood, but their molecular pathogenesis remains unknown. Most PNETs are indolent but have malignant potential. The biological behavior of an individual PNET is unpredictable; higher tum...
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Pancreatic neuroendocrine tumors are relatively uncommon lesions that arise in the endocrine cells of the pancreas. There is variability in the molecular biology of these tumors, making them difficult to treat. Until recently, there have been few systemic treatment options. With the growing incidence of pNETs, multiple clinical trials are underway to determine the route of treatment that will b...
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Pancreatic Endocrine Tumors (PNETs) represent a rare, but important subset of pancreatic neoplasms. These tumors account for 2–4% of all clinically detected pancreatic tumors. Their overall incidence is approximately 1 of 100 000 people per year [1,2]. PNETs consist of single or multiple benign or malignant neoplasms and are associated with multiple endocrine neoplasia type 1 (MEN1) in 10– 20% ...
متن کاملCurrent understanding of the molecular biology of pancreatic neuroendocrine tumors.
Pancreatic neuroendocrine tumors (PanNETs) are complicated and often deadly neoplasms. A recent increased understanding of their molecular biology has contributed to expanded treatment options. DNA sequencing of samples derived from patients with PanNETs and rare genetic syndromes such as multiple endocrine neoplasia type 1 (MEN1) and Von Hippel-Lindau (VHL) syndrome reveals the involvement of ...
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Pancreatic neuroendocrine tumors are usually indolent (slow-growing) by nature and develop over the course of many years. Pancreatic neuroendocrine tumors are usually more indolent, with better prognosis than adenocarcinoma of the pancreas (Carriaga & Henson, 1995). However, aggressive, fast growing pancreatic neuroendocrine tumors exist and different types of pancreatic neuroendocrine tumors e...
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ژورنال
عنوان ژورنال: Chinese Journal of Cancer
سال: 2013
ISSN: 1000-467X,1944-446X
DOI: 10.5732/cjc.012.10295